|The Immune system
is controlled by a specific set of regulatory and effector elements
that have to be finely and constantly tuned to maintain its homeostasis
throughout the longevity. ‘Immunity’ encompasses active processes
to protect against internal and/or external threaten such infection.
As the counterpart of immunity, immune system develop exquisite mechanism,
known as ‘Tolerance’, which actively induce a state of unresponsiveness
of the immune system to various substance that have the capacity to
elicit immune responses.
The balance between these distinct immune compartments, called
‘Immunological homeostasis’, is exquisitely retained in a healthy
individual and the breakdown of this symmetry can trigger inflammation
driving much human pathology and disease, including autoimmune diseases,
cancer and, potentially, neurodevelopmental disorders. Accordingly,
we are very interested in uncovering novel mechanisms controlling
function and development of immune cells, and how the failure of
these mechanisms lead to the development and progression and inflammatory
disorders. Specifically, we aim to identify host- (especially immune
and neuronal) and bacteria-factors that affect immunological homeostasis
in normal and diseases condition and, eventually, to apply these
to help with the treatment of human inflammatory disorders such
as autoimmunity, cancer, and neurodevelopmental disorders.
For more details, please visit the lab homepage (https://www.kwonhklab.com/).