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Lee H, Hwang I, Park S, Hong S, Hwang B, Cho Y, Son J, Yu JW. MPTP-driven NLRP3 inflammasome activation in
microglia plays a central role in dopaminergic neurodegeneration. Cell Death Differ (2018) doi: 10.1038/s41418-018-0124-5
Ann SJ, Kim KK, Cheon EJ, Noh HM, Hwang I, Yu JW, Park S, Kang SM, Manabe I, Miller YI, Kim S, Lee SH.
Palmitate and minimally-modified low-density lipoprotein cooperatively promote inflammatory responses in macrophages.
PLoS One (2018) 13, e0193649
Hong S, Yu JW. Prolonged exposure of lipopolysaccharide induces NLRP3-independent maturation and secretion of
interleukin (IL)-1beta in macrophages. J Microbiol Biotechnol (2018) 28, 115-121
Son S, Hwang I, Han SH, Shin JS. Yu JW. Advanced glycation end products impair NLRP3 inflammasome-mediated
immune responses in macrophages. J Biol Chem (2017)292, 20437-20448
Jeon SA, Lee E, Hwang I, Han B, Park S, Son S, Yang J, Hong S, Kim CH, Son J, Yu JW. NLRP3 inflammasome
Contributes to Lipopolysacchairde-induced Depressive-like Behaviors via Indoleamine 2.3-dioxygenase induction
lnt J Neuropsychopharmcol (2017) 20, 896-906
Yang J, Lee KM, Park S, Cho Y, Lee E, Park JH, Shin SO, Son J, Yoon SS, Yu JW. Bacterial secretant from
Pseudomonas aeruginosa dampens inflammasome activation in a quorum sensing-dependent manner.
Front Immunol (2017)8. 333
Lee JH, Lee HH, Kim HW, Yu JW, Kim KN, Kim KM. Immunomodulatory/anti-inflammatory effect of ZOE-based dental
materials. Dent Mater (2017) 33, e1-e12
Yu JW, Lee MS. Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance.
Arch Pharm Res (2016) 39, 1503-1518
Jang J*, Park S*, Hur HJ, Cho HJ, Hwang I, Kang YP, Im I, Lee H, Lee E, Yang W, Kang HC, Kwon SW, Yu JW**,
Kim DW**. 25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation
of the NLRP3 inflammasome activation. Nat Commun (2016) 7, 13129 (**Co-correspondence)
Kim JH, Park JH, Eisenhut M, Yu JW, Shin JI. Inflammasome activation by cell volume regulation and inflammation-
associated hyponatremia: A vicious cycle. Med Hypotheses (2016) 93, 117-121
Oh JE, Kim BC, Chang DH, Kwon M, Lee SY, Kang D, Kim JY, Hwang I, Yu JW, Nakae S, Lee HK. Dysbiosis-induced
IL-33 contributes to impaired antiviral immunity in the genital mucosa. Proc Natl Acad Sci USA (2016) 113, E762-E771
Hwang I, Lee E, Jeon SA, Yu JW. Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation. Biochem
Biophys Res Commun (2015) 467, 973-978
Park S, Won JH, Hwang I, Hong S, Lee HK, Yu JW. Defective mitochondrial fission augments NLRP3 inflammasome
activation. Sci Rep (2015) 5, 15489
Won JH, Park S, Hong S, Son S, Yu JW. Rotenone-induced impairment of mitochondrial electron transport chain confers
a selective priming signal for NLRP3 inflammasome activation. J Biol Chem (2015) 290, 27425-27437
Hwang I, Yang J, Hong S, Lee EJ, Lee SH, Fernandes-Alnemri T, Alnemri ES, Yu JW. Non-transcriptional regulation
of NLRP3 inflammasome signaling by IL-4. Immunol Cell Biol (2015) 93, 591-599
Park S, Juliana C, Hong S, Datta P, Hwang I, Fernandes-Alnemri T, Yu JW*, Alnemri ES*. The mitochondrial anti-viral
protein MAVS associates with NLRP3 and regulates its inflammasome activity. J Immunol (2013) 191, 4358-4366
(*Co-correspondence)
Kim EH, Won JH, Hwang I, Yu JW. Cobalt chloride-induced hypoxia ameliorates NLRP3-mediated caspase-1 activation
in mixed glial cultures. Immune Netw (2013) 13, 141-147
Yu JW*, Farias A, Hwang I, Fernandes-Alnemri T, Alnemri ES. Ribotoxic stress through p38 mitogen-activated protein kinase
activates in vitro the human pyrin inflammasome. J Biol Chem (2013) 288, 11378-11383 (*Co-correspondence)
Hong S, Hwang I, Lee YS, Park S, Lee WK, Fernandes-Alnemri T, Alnemri ES, Kim YS, Yu JW. Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death Cancer Lett. (2013) 331, 183-191
Hwang I, Park S, Hong S, Kim EH, Yu JW. Salmonella promotes ASC oligomerization-dependent caspase-1 activation.
Immune Netw (2012) 12, 284-290
Hong S, Park S, Yu JW. Pyrin domain (PYD)-containing inflammasome in innate immunity. J Bacteriol Virol (2011) 41,133-146
Kim JY, Lee JY, Kim DG, Koo GB, Yu JW, Kim YS. TRADD is critical for resistance to TRAIL-induced cell death through NF-kB activation. FEBS Lett (2011) 585, 2144-2150
Kim KJ, Yu JW, Hwang HS, Choi EJ. CIIA is a regulator of detachment-induced cell death. Cancer Res (2010) 70, 6352-6358
Yu JW, Yang R, Kim YS. Differential cytoprotective effect of copper- and iron-containing chlorophyllins against oxidative
stress-mediated cell death. Free Radic Res (2010) 44, 655-667
Fernandes-Alnemri T*, Yu JW*, Juliana C, Solorzano L, Kang SW, Wu J, Datta P, McCormick M, Huang L, McDermott E,
Eisenlohr L, Landel CP, Alnemri ES. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat
Immunol (2010) 11, 385-393(* equal contribution)
Juliana C, Fernandes-Alnemri T, Wu J, Solorzano L, Datta P, Yu JW, Meng R, Quong AA, Latz E, Scott CP, Alnemri ES.
Anti-inflammatory compounds parthenolide and Bay 11-7802 are direct inhibitors of the inflammasome. J Biol Chem (2010) 285,
9792-9802
Fernandes-Alnemri T*, Yu JW*, Wu J, Datta P, Alnemri ES. AIM2 activates the inflammasome and cell death in response to
cytoplasmic DNA. Nature (2009) 458, 509-513 (* equal contribution)
Jeru I, Duquesnoy P, Fernandes-Alnemri T, Cochet E, Yu JW, Lackmy-Port-Lis M, Grimprel E, Landman-Parker J, Hentgen
V, Marlin S, McElreavey K, Sarkisian T, Grateau G, Alnemri ES, Amselem S. Mutations in NALP12 cause hereditary periodic
fever syndromes. Proc Natl Acad Sci USA (2008) 105, 1614-1619
Yu JW, Fernandes-Alnemri T, Datta P, Wu J, Juliana C, Solorzano L, McCormick M, Zhang Z, Alnemri ES. Pyrin activates
the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Mol Cell (2007) 28, 214-227
T Fernandes-Alnemri, J Wu, J-W Yu, P Datta, B Miller, W Janchowski, S Rosenberg, J Zhang, ES Alnemri. The pyroptosome:
a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ (2007)
14(9): 1590-1604
J-W Yu*, J Wu*, Z Zhang, P Datta, I Ibrahimi, S Taniguchi, J Sagara, T Fernandes-Alnemri, ES Alnemri. Cryopyrin and pyrin
activate caspase-1, but not NF-kB, via ASC oligomerization. Cell Death Differ (2006) 13(2): 236-249
Park HS*, Yu JW*, Cho JH*, Kim MS*, Huh SH, Ryoo K, Choi EJ. Inhibition of Apoptosis-Signaling Kinase 1 (ASK1) by nitric
oxide through a thiol-redox mechanism. J Biol Chem (2004) 279(9): 7584-7590 (*equal contribution)
Yu JW, Yoon SS, Yang R. Iron chlorin e6 scavenges hydroxyl radical and protects human endothelial cells against hydrogen
peroxide toxicity. Biol Pharm Bull (2001) 24(9): 1053-1059
Yang R, Yu JW, Shin DB. Free radical scavenging activities of chlorophyll derivatives. Kor J Gerontol (1999) 9(2): 36-40
Yang R, Son SC, Yu JW, Shin DB. Purification and characterization of a cysteinesulfinate decarboxylase from porcine liver.
Kor J Gerontol (1997) 7(2): 58-63

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