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HOME : 연구활동 : 윤상선 교수님

Jung J, Yoo JE, Choe YH, Park SC, Lee HJ, Lee HJ, Noh B, Kim SH, Kang GY, Lee KM, Yoon SS, Jang DS, Yoon JH,
Hyun YM, Choi JY. Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear.
Cell Host Microbe. 2019 Mar 20. pii: S1931-3128(19)30061-7.
Hwang W, Yoon SS. Virulence Characteristics and an Action Mode of Antibiotic Resistance in Multidrug-Resistant
Pseudomonas aeruginosa. Sci Rep. 2019 Jan 24;9(1):487.
Kim CY, Lee M, Lee K, Yoon SS, Lee I. Network-based genetic investigation of virulence-associated phenotypes in
methicillin-resistant Staphylococcus aureus. Sci Rep. 2018 Jul 17;8(1):10796.
Jung IY, Jeong SJ, Lee KM, Ahn JY, Ku NS, Han SH, Choi JY, Yong D, Yoon SS, Song YG, Jeong SH, Kim JM, Lee K.
Risk factors for mortality in patients with Pseudomonas aeruginosa pneumonia: Clinical impact of mucA gene mutation.
Respir Med. 2018 Jul;140:27-31.
Kim B, Park JS, Choi HY, Yoon SS, Kim WG. Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas
aeruginosa: a connection between quorum sensing and c-di-GMP. Sci Rep. 2018 Jun 5;8(1):8617.
Toyofuku M, Yoon SS. Nitric Oxide, an Old Molecule With Noble Functions in Pseudomonas aeruginosa Biology.
Adv Microb Physiol. 2018;72:117-145.
Kim HY, Yu SM, Jeong SC, Yoon SS, Oh YT. Effects of flaC Mutation on Stringent Response-Mediated Bacterial Growth,
Toxin Production, and Motility in Vibrio cholera. J Microbiol Biotechnol. 2018 May 28;28(5):816-820.
Kim HY, Go J, Lee KM, Oh YT, Yoon SS. Guanosine tetra- and pentaphosphate increase antibiotic tolerance by reducing
reactive oxygen species production in Vibrio cholerae. J Biol Chem. 2018 Apr 13;293(15):5679-5694.
Yoon MY, Yoon SS. Disruption of the Gut Ecosystem by Antibiotics. Yonsei Med J. 2018 Jan;59(1):4-12. Review.
Lee K, Lee KM, Kim D, Yoon SS., Molecular determinants of the matrix thickening of a dual-species Pseudomonas
aeruginosa and Enterococcus faecalis biofilm. Appl Environ Microbiol. 2017 Aug 25. pii: AEM.01182-17.
Yang J, Lee KM, Park S, Cho Y, Lee E, Park JH, Shin OS, Son J, Yoon SS, Yu JW. Bacterial Secretant from
Pseudomonas aeruginosa Dampens Inflammasome Activation in a Quorum Sensing-Dependent Manner.
Front Immunol. 2017 Mar 27;8:333.
Choi JY, Yoon SS, Kim SE, Ahn Jo S. KDM4B histone demethylase and G9a regulate expression of vascular adhesion
proteins in cerebral microvessels. Sci Rep. 2017 Mar 22;7:45005.
Lee K, Yoon SS. Pseudomonas aeruginosa Biofilm, a Programmed Bacterial Life for Fitness. J Microbiol Biotechnol.
2017 Jun 28;27(6):1053-1064. Review.
Lee KM, Lee K, Go J, Park IH, Shin JS, Choi JY, Kim HJ, Yoon SS. A Genetic Screen Reveals Novel Targets to
Render Pseudomonas aeruginosa Sensitive to Lysozyme and Cell Wall-Targeting Antibiotics. Front Cell Infect Microbiol.
2017 Mar 1;7:59.
Alrahman MA, Yoon SS. Identification of essential genes of Pseudomonas aeruginosa for its growth in airway mucus.
J Microbiol. 2017 Jan;55(1):68-74.
Oh YT, Kim HY, Kim EJ, Go J, Hwang W, Kim HR, Kim DW, Yoon SS. Selective and Efficient Elimination of Vibrio
cholerae with a Chemical Modulator that Targets Glucose Metabolism. Front Cell Infect Microbiol. 2016 Nov 16;6:156.
C. Ahn, S. S. Yoon, T. S. Yong, S. H. Jeong, and K. Lee. The Resistance Mechanism and Clonal Distribution of
Tigecycline-Nonsusceptible Klebsiella pneumoniae Isolates in Korea. Yonsei Med J. 2016, 57(3):641-6.
M. Y. Yoon, K. B. Min, K-M. Lee, Y. Yoon, Y. Kim, Y. T. Oh, K. Lee, J. Chun, B-Y. Kim, S-H. Yoon, I. Lee, C. Y. Kim
and S. S. Yoon*. A single gene of a commensal microbe affects host susceptibility to enteric infection. Nat Commun.
2016, 13;7:11606.
K. Lee, K-M. Lee, J. Go, J-C. Ryu, J-H. Ryu, and S. S. Yoon*. The ferrichrome receptor A as a new target for
Pseudomonas aeruginosa virulence attenuation. FEMS Microbiol Lett. 2016, 363(11).
S. Hwang, C. Y. Kim, S-G. Ji, J. Go, H. Kim, S. Yang, H. J. Kim, A. Cho, S. S. Yoon* and I. Lee*. Network-assisted
investigation of virulence and antibiotic-resistance systems in Pseudomonas aeruginosa. Sci Rep. 2016, 19;6:26223.
Y. T. Oh, K-M. Lee, W. Bari, H. Y, Kim, H. J. Kim, S. S. Yoon*. Cholera toxin production induced upon anaerobic
respiration is suppressed by glucose fermentation in Vibrio cholerae, J Microbiol Biotechnol, 2016, 26(3):627-36.
H. J. Kim, H. S. Kim, J. M. Lee, S. S. Yoon, D. Yong. Rapid detection of Pseudomonas aeruginosa and Acinetobacter
baumannii Harboring bla(VIM-2), bla(IMP-1) and bla(OXA-23) genes by using loop-mediated isothermal amplification
methods, Ann Lab Med, 2016, 36(1):15-22.
M. Gi, K-M. Lee, S. C. Kim, J. H. Yoon, S. S. Yoon*, J. Y. Choi*. A novel siderophore system is essential for the growth
of Pseudomonas aeruginosa in airway mucus, Sci Rep, 2015, Oct 8;5:14644.
J. Go, K-M. Lee, Y. Park, S. S. Yoon*. Extended longevity and robust early-stage development of Caenorhabditis elegans
by a soil microbe, Lysinibacillus sphaericus. Environ Microbiol Rep, 2014 Dec;6(6):730-7.
S. S. Yoon, E. K. Kim, W. J. Lee. Functional genomic and metagenomic approaches to understanding gut microbiota-animal
mutualism , Curr Opin Microbiol, 2015, Apr;24:38-46.
Y. H. Leem, S. S. Yoon, Y. H. Kim, S. A. Jo. Disrupted MEK/ERK signaling in the medial orbital cortex and dorsal
endopiriform nuclei of the prefrontal cortex in a chronic restraint stress mouse model of depression. Neurosci Lett,
2014, Sep 19;580:163-8.
Y. T. Oh, K-M. Lee, W. Bari, D. M. Raskin, and S. S. Yoon*. (p)ppGpp, a small nucleotide regulator, directs the
metabolic fate of glucose in Vibrio cholerae, J. Biol. Chem. under revision
S. S. Yoon, E. Kim, W-J. Lee. Functional metagenomics for understanding gut microbiota-animal mutualism, Current
Opinion in Microbiology, 2015, 24:38-46
M. Y. Yoon, K. Lee and S. S. Yoon*. Protective role of gut commensal microbes against intestinal infections. J. Microbiol,
2014, 52(12): 983-989
K. B. Min, K-M. Lee, Y. T. Oh and S. S. Yoon*. Nonmucoid Conversion of Mucoid Pseudomonas aeruginosa Induced by
Sulfate-stimulated Growth. FEMS Microbiology Letters, 2014, 360(2):157-166.
M. Gi, J. Jeong, K. Lee, Y. Park, M. Toyofuku, S. S. Yoon*, J. Y. Choi*. A Drug Repositioning Screen Identified Pentetic
Acid as a Potential Therapeutic Agent to Suppress Elastase-mediated Virulence of Pseudomonas aeruginosa. Antimicrob.
Agents and Chemother., 2014, 58(12):7205-14.
K. B. Min, K-M. Lee, Y. T. Oh and S. S. Yoon*. Nonmucoid Conversion of Mucoid Pseudomonas aeruginosa Induced
by Sulfate-stimulated Growth. FEMS Microbiology Letters, 2014 in press.
M. Gi, J. Jeong, K. Lee, Y. Park, M. Toyofuku, S. S. Yoon*, J. Y. Choi*. A Drug Repositioning Screen Identified Pentetic
Acid as a Potential Therapeutic Agent to Suppress Elastase-mediated Virulence of Pseudomonas aeruginosa. Antimicrob.
Agents and Chemother., 2014 in press.
* Highlighted in MDLinx
Jeong S. J., Yoon S. S., Bae I. K., Jeong S. H., Kim J. M., Lee K. Risk factors for mortality in patients with bloodstream
infections caused by carbapenem-resistant Pseudomonas aeruginosa: clinical impact of bacterial virulence and strains
on outcome. Diagn Microbiol Infect Dis. 2014 Jul 17. [Epub ahead of print]
H. J. Kim, Y. J. Kim, D. E. Yong, K. Lee, J. H. Park, J. M. Lee* and S. S. Yoon*. Loop-mediated Isothermal Amplification
of vanA Gene Enables Rapid and Naked-eye Detection of Vancomycin-Resistant Enterococci Infection. J. of Microbiol.
Methods, 2014 Sep, 104:61-6
J. Go, K-M. Lee, Y. Park, S. S. Yoon*. Extended Longevity and Robust Early-stage Development of Caenorhabditis
elegans by a Soil Microbe, Lysinibacillus sphaericus, Environmental Microbiology Reports, 2014, Article first published
online: 11 AUG 2014 | DOI: 10.1111/1758-2229.12196.
Y. T. Oh, Y. Park, M. Y. Yoon, W. Bari, J. Go, K-M. Lee, S. S. Yoon*. Cholera toxin production during anaerobic TMAO
respiration is mediated by stringent response in Vibrio cholerae, J. Biol. Chem. 2014, 289(19): 13232-42
M. Y. Yoon, K-M. Lee, J. Go, Y. Y. Yoon, Park, S. C. Kim, and G. W. Tannock, S. S. Yoon*. Functional Screen of a
Metagenomic Library Reveals Operons Responsible for Enhanced Intestinal Colonization by Gut Commensals. Appl.
Environ. Microbiol., 2013, 79(12): 3829-38
*Selected as a “Spotlight” of the issue
*Selected as a “Must-read” paper by Faculty of 1,000 (http://f1000.com/prime/718028126)
Kim M. J., Bae I. K., Jeong S. H., Kim S. H., Song J. H., Choi J. Y., Yoon S. S., Thamlikitkul V., Hsueh P. R., Yasin R. M.,
Lalitha M. K., Lee K. Dissemination of metallo-β-lactamase-producing Pseudomonas aeruginosa of sequence type 235 in
Asian countries. J. Antimicrob. Chemother. 2013 Jul 9. [Epub ahead of print]
S. J. Jeong, S. S. Yoon, S. H. Han, D. E. Yong, C. O. Kim, J. M. Kim. Evaluation of humoral immune response to
nosocomial pathogens and functional status in elderly patients with sepsis. Arch. Gerontol. Geriatr., 2013 Aug. 30.
[Epub ahead of print]
J. M. Park, K-B Kim, J-E Lee, Y. Park, S. S. Yoon, H. M. Jeong, H-I. Lee, Thermoresponsive Fluorinated Polyacrylamides
with Low Cytotoxicity, Polymer Chemistry, 2013, (4):2219-2223
K-M. Lee, Y. Park, Wasimul B., M. Y. Yoon, J. Go, S. C. Kim, S. S. Yoon. Activation of Cholera Toxin Production by
Anaerobic Respiration of Trimethylamine N-oxide in Vibrio cholerae, J. Biol. Chem., 2012, 287(47): 39742-39752
Wasimul B., K-M. Lee, S. S. Yoon. Structural and Functional Importance of Outer Membrane Proteins in Vibrio cholerae
flagellum. The Journal of Microbiology, 2012, 50(4): 631-637
S. Kim, M. Rahman, S. Y. Seol, S. S. Yoon*, J. Kim*. Pseudomonas aeruginosa Bacteriophage PA1O Requires
Type IV Pili for Infection and Shows Broad Bactericidal and Biofilm Removal Activities. Appl. Environ. Microbiol. 2012,
78(17):6380-6385 (*co-corresponding authors)
K-M. Lee, J. Go, M. Y. Yoon, Y. Park, S. C. Kim, D. E. Yong, and S. S. Yoon. Vitamin B12-mediated Restoration of
Defective Anaerobic Growth Leads to Reduced Biofilm Formation in Pseudomonas aeruginosa. Infection and Immunity,
2012, 80(5):1639-1649
K-M. Lee, J. Lim, S. Nam, M. Y. Yoon, Y-K. Kwon, B.Y. Jung, S. Park, S. S. Yoon. Inhibitory Effects of Broccoli Extract
on Escherichia coli O157:H7 Quorum Sensing and in vivo Virulence. FEMS Microbiology Letters, 2011, 321(1):67-74
Wasimul B., Y.-J. Song and S. S. Yoon. A unique metabolite produced by Vibrio cholerae O1 El Tor Biotype Mediates
Immune Suppression in Cultured Host Cells. Infection and Immunity, 2011, 79(8):3149-3158
K-M. Lee, M. Y. Yoon, Y. J. Park and S. S. Yoon. Anaerobiosis-induced Loss of Cytotoxicity is Due to Inactivated
Quorum Sensing in Pseudomonas aeruginosa. Infection and Immunity, 2011, 79(7):2792-2800
M. Y. Yoon, K-M. Lee, Y. J. Park and S. S. Yoon. Contribution of Cell Elongation to the Biofilm Formation of
Pseudomonas aeruginosa during Anaerobic Respiration. PLoS One, 2011, 6:e16105.
*Selected as a “Must-read” paper by Faculty of 1,000 (http://f1000.com/9026960)
S. S. Yoon, Anaerobiosis of Pseudomonas aeruginosa: Implications for Treatment of Airway Infection. Journal of
Bacteriology and Virology, 2010, 40:59-66
M. Y. Yoon, K-M. Lee, S. H. Jeong, J. Kim and S. S. Yoon. Heterogeneous virulence potentials and high antibiotics
resistance of Pseudomonas aeruginosa strains isolated from Korean pneumonia patients. The Journal of Microbiology,
2010, 48:518-25
Vibrio cholerae proteome-wide screen for immunostimulatory proteins identifies phosphatidylserine decarboxylase as a
novel toll-like receptor 4 agonist. PLoS Pathogens, 2009, 5(8): e1000556
A. Rolfs, W. Montor, S.S. Yoon, Hu, Yanhui, Bhullar, Bhupinder, Kelley, Fontina, McCarron, Seamus, Jepson,
Daniel A., Shen, Binghua, Taycher, Elena, Mohr, Stephanie E., Zuo, Dongmei, Williamson, Janice, Mekalanos, John,
LaBaer, Joshua, Production and sequence validation of a complete full length ORF collection for the pathogenic
bacterium Vibrio cholerae. PNAS, 2008, 105:4364-9.
S.S. Yoon and John J. Mekalanos. Decreased Potency of Vibrio cholerae Sheathed Flagellum to Trigger Host Innate
Immunity. Infection and Immunity, 2008, 76:1282-8.
S.S. Yoon, A.C. Karabulut, J.D. Lipscomb, R.F. Hennigan, S.V. Lymar, S.L. Groce, A.B. Herr,M.L. Howell, P.J. Kiley,
M.J. Schurr, B.Gaston, K.Choi, H.P. Schweizer and D.J Hassett. Two-Pronged Survival Strategy for Pseudomonas
aeruginosa, Lacking the Capacity to Degrade NitricOxide During Anaerobic Respiration. The EMBO Journal.
2007. 26:3662-72.
S.S. Yoon and John J. Mekalanos. 2,3-Butanediol synthesis and the emergence of the Vibrio cholerae El Tor biotype.
Infection and Immunity. 2006. 74:6547-6556
*Selected as a “Spotlight” of the issue
S.S. Yoon, Coakley R, Lau GW, Lymar SV, Gaston B, Karabulut AC, Hennigan RF, Hwang S, Buettner G, Schurr MJ,
Mortensen JE, Burns JL, Speert D, Boucher RC and D.J. Hassett. Anaerobic Killing of Mucoid Pseudomonas aeruginosa
by Acidified Nitrite Derivatives under Cystic Fibrosis Airway Conditions. Journal of Clinical Investigation. 2006. 116:436-446.
S.S. Yoon and D.J. Hassett. Chronic Pseudomonas aeruginosa Infection In Cystic Fibrosis Airway Disease:
Understanding Metabolic Changes That Unravel Novel Drug Targets. Expert Reviews of Anti-Infective Therapy 2004.
Lauriano C.M., J.R. Barker, S.S. Yoon, F.E. Nano, B.P. Arulanandam, D.J. Hassett, and K.E. Klose. MglA regulates
transcription of virulence factors necessary for Francisella tularensis intra-amoebae and intra-macrophage survival. PNAS,
D.J. Hassett, J. Cuppoletti, B. Trapnell, J.J. Rowe, S.S. Yoon, G.M. Hilliard, K. Parvatiyar, M.C. Kamani, D.J. Wozniak,
and S.-H. Huang. Anaerobic metabolism and quorum sensing By Pseudomonas aeruginosa in Biofilms in Chronically
Infected Cystic Fibrosis Airways: Rethinking Antibiotic Treatment Strategies and Drug Targets. Adv. Drug Delivery Rev.
2002. 54: 1425-1443..
S.S. Yoon, R.F. Hennigan, G.M. Hilliard, U.A. Ochsner, K. Parvatiyar, M.C. Kamani, H.L. Allen, T.R. DeKievit, P.R.
Gardner, U. Schwab, J.J. Rowe, B.H. Iglewski, T.R. McDermott, R.P. Mason, D.J. Wozniak, R.E.W. Hancock, M.R. Parsek,
T.L. Noah, R.C. Boucher and D.J. Hassett. Pseudomonas aeruginosa Anaerobic Respiration in Biofilms: Relationships to
Cystic Fibrosis Pathogenesis. Developmental Cell 2002. 3: 631-642.
*Editorial Comments on This Paper
- Costerton JW. Anaerobic biofilm infections in cystic fibrosis. Molecular Cell. 2002. 10:699
- Schubert C. Breaking up the biofilm. Nature Medicine 2002. 8:1354.
Han MJ, S.S. Yoon and Lee SY. Proteome analysis of metabolically engineered Escherichia coli producing Poly
(3- hydroxybutyrate). J. Bac. 2001. 183:301-8.

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