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HOME : 연구활동 : 김종선 교수님

Saet-byul Lee, Junhoe Cha, Im-kyung Kim, Joo Chun Yoon, Hyo Joon Lee, Sang Woo Park, Sunjung Cho,
Dong-Ye Youn, Heyja Lee, Choong Hwan Lee, Jae Myun Lee, Kang Young Lee, Jongsun Kim. (2014) A high-throughput
assay of NK cell activity in whole blood and its clinical application. Biochemical and Biophysical Research
Communications 445, 584?590.
Hae mi Lee, Kyung-Sup Kim, Jongsun Kim. (2014) A comparative study of the effects of inhibitory cytokines on human
natural killer cells and the mechanistic features of transforming growth factor-beta. Cellular Immunology 290, 52?61.
S.B. Lee, H. Park, J. Koh, J. Kim (2013) Evaluation of the bioefficacy of a stabilized form of human growth hormone
(SP-hGH). Horm. Metab. Res. 45, 1-6.
Wookjin Shin, Jongsun Kim (2012) The effects of recombinant synucleins and IGF-1 on cancer cell migration. J.Bacteriol.
Virol. 42, 133-151.
Jiae Koh, Saet-byul Lee, Hyunju Park, Hyo Jun Lee, Nam Hoon Cho, Jongsun Kim (2012) Susceptibility of CD24+ ovarian
cancer cells to anti-cancer drugs and natural killer cells. BBRC 427, 373-378.
H. Park, S.-B. Lee, J. Kim (2012) Metabolic effects of a stabilizing peptide fusion protein of leptin in normal mice. Horm.
Metab. Res. 44, 422-428.
Agata Rekas, Keun Jae Ahn, Jongsun Kim, John A. Carver (2012) The chaperone activity of 1-synuclein: Utilizing deletion
mutants to map its interaction with target proteins. Proteins 80, 1316-1325
J.I. Shin, K.S. Song, H. Kim, N.H. Cho, J. Kim, H. S. Kim, J.S. Lee (2011) The gene expression profile of matrix
metalloproteinases and their inhibitors with Henoch-Schonlein purpura. British J. Dermatology 164, 1348-1355.
Hyung-Ran Kim, Yong-Joon Chwae, Jongsun Kim (2010) Identification of the amino acid sequence motif for conventional
PKC-mediated regulation of NKp46 surface expression. Scandinavian Journal of Immunology 71, 413-419.
Hyung-Ran Kim, Kyoung-Ho Lee, Su Jung Park, So Young Kim, Young Keun Yang, Jinsung Tae, Jongsun Kim (2009) Anti-
cancer activity and mechanistic features of a NK cell activating molecule. Cancer Immunology and Immunotherapy 58,
Saet-byul Lee, Sang Myun Park, Keun Jae Ahn, Kwang Chul Chung, Seung R. Paik, Jongsun Kim (2009) Identification of the
amino acid sequence motif of alpha-synuclein responsible for macrophage activation. Biochemical and Biophysical Research
Communications 381, 39-43.
Young Mok Kim, Hye Ja Lee, Jung Eun Lee, Hae Yeong Kim, Jongsun Kim (2009) Expression of human interferone alpha-1
with enhanced stability via the tagging system of a stabilizing peptide. Protein Expression and Purification 63, 140-146.
Ji-Young Park, Kwang Soo Kim, Saet-Byul Lee, Jae-Sung Ryu, Kwang Chul Chung, Young-Kug Choo, Ilo Jou, Jongsun Kim
and Sang Myun Park (2009) On the mechanism of internalization of alpha-synuclein intomicroglia : roles of ganglioside GM1
and lipid raft. Journal of neurochemistry 110, 400-411
Keun Jae Ahn, Jongsun Kim, Mijin Yun, Jeon Han Park and Jong Doo Lee (2009) Enzymatic properties of the N- and
C-terminal halves of human hexokinase II. BMB reports 42(6), 350-355.
Hae Jin Song, Joongkyu Park, Su Ryeon Seo, Jongsun Kim, Seung R. Paik, Kwang Chul Chung (2008) Down syndrome
critical region 2 protein inhibits the transcriptional activity of peroxisome proliferator-activated receptor β in HEK293 cells.
Biochemical and Biophysical Research Communications 21, 376(3), 478-82.
Jae-Woo Park, In-Hwan Lee, Ji-Sook Hahn, Jongsun Kim, Kwang Chul Chung, Seung R. Paik (2008) Disintegration of
amyloid fibrils of α-synuclein by dequalinium. Biochim Biophys Acta 1780(10), 1156-1161.
Hyung-Ran Kim, Kunhong Kim, Kyoung-Ho Lee, Se Jong Kim, Jongsun Kim (2008) Inhibition of Casein Kinase 2 Enhances
the Death Ligand- and NK Cell-Induced Hepatocellular Carcinoma Cell Death. Clinical Experimental Immunol. 152, 336-344.
Yong-Joon Chwae, Jae Myun Lee, Hyung-Ran Kim, Eun Joo Kim, Seung Tae Lee, Jae-Won Soh, Jongsun Kim (2008) Amino
Acid Sequence Motifs for PKC-Mediated Membrane Trafficking of the Inhibitory Killer Ig-like Receptor. Immunol. Cell Biol. 86,
Sang Myun Park, Jongsun Kim (2008) A soluble and heat-resistant form of hantavirus nucleocapsid protein for the
serodiagnosis of HFRS. J. Virol. Methods 147, 1-9.
Yong-Joon Chwae, Jae Myun Lee, Eun Joo Kim, Seung Tae Lee, Jae-Won Soh, Jongsun Kim (2007) Activation-induced
upregulation of inhibitory killer Ig-like receptors is regulated by protein kinase C. Immunol. Cell Biol., 85, 220-228.
Ji-Ho Yoo, Eungkweon Kim, Jongsun Kim, Hyun-Soo Cho (2007) Crystallization and preliminary crystallographic analysis of
the fourth FAS1 domain of human BigH3. Acta Crystallography F63, 893-895.
Keun Jae Ahn, Seung R. Paik, Kwang Chul Chung, Jongsun Kim (2006) Amino acid sequence motifs and mechanistic
features of the membrane translocation of a-synuclein. J. Neurochem. 97, 265-279.
Hyun Il Cho, Yong-Joon Chwae, Sang Myun Park, Jongsun Kim (2006) Association of killer cell Ig-like receptor (KIR) with an adaptor protein Shc. Immune Networks 6, 67-75.
Ji Won Um, Do Sik Min, Hyewhon Rhim, Jongsun Kim, Seung R. Paik, Kwang Chul Chung (2006) Parkin ubiquitinates and
promotes the degradation of RanBP2. J. Biol. Chem. 281, 3595-3603.
Choong-Hwan Lee, Hyun Jin Kim, Jung-Ho Lee, Hyun-Ju Cho, Jongsun Kim, Kwang Chul Chung, Seungho Jung, Seung R.
Paik (2006) Dequalinium-induced protofibril formation of a-synuclein. J. Biol. Chem. 281, 3463-3472.
Tae Woo Jung, Ji Young Lee, Wan Sup Shim, Eun Seok Kang, Jongsun Kim, Chul Woo Ahn, Hyun Chul Lee, Bong Soo Cha
(2006) Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. BBRC 343, 564-570.
Eun Joo Kim, Jee Young Sung, Hyun Jung Lee, Hyewhon Rhim, Masato Hasegawa, Takeshi Iwatsubo, Do Sik Min, Jongsun
, Seung R. Paik, Kwang Chul Chung (2006) Dyrk1A phosphorylates a-synuclein and enhances intracellular inclusion
formation. J. Biol. Chem. 281, 33250-33257.
Hyun Jin kim, Daekyun Lee, Choong-Hwan Lee, Kwang Chul Chung, Jongsun Kim, Seung R. Paik (2006) Calpain-resistant
fragment(s) of a-synuclein regulates the synuclein-cleaving activity of 20S proteosome. Archives Biochem. Biophys. 455,
Tae Woo Jung, Ji Young Lee, Wan Sup Shim, Eun Seok Kang, Jongsun Kim, Chul Woo Ahn, Hyun Chul Lee, Bong Soo Cha
(2006) Adiponectin protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity. Biochem.
Pharmacol. 72, 616-623.
Eui Nam Lee, Young Mok Kim, Hye Ja Lee, Sang Woo Park, Han Young Jung, Jae Myun Lee, Yong-Ho Ahn, & Jongsun Kim
(2005) Stabilizing Peptide Fusion for Solving the Stability and Solubility Problems of Therapeutic Proteins. Phar. Res. 22,
Sung JY, Park SM, Lee CH, Um JW. Lee HJ, Kim J, Oh YJ, Lee ST, Paik SR, Chung KC (2005) Proteolytic cleavage of
extracellular secreted a-synuclein via matrix metalloproteinases. J. Biol. Chem. 280, 25216-25224.
Sang Myun Park, Keun Jae Ahn, Han Young Jung, Jeon Han Park, Jongsun Kim (2004) Effects of novel peptides derived
from the acidic tail of synuclein (ATS) on the aggregation and stability of fusion proteins. Protein Engineering, Design &
Selection 17, 251-260.
Hyoung-Ran Kim, Hyun-Joo Park, Jeon Han Park, Se Jong Kim, Kunhong Kim, Jongsun Kim (2004) Characteristics of the
killing mechanism of human natural killer cells against hepatocellular carcinoma cell lines hEPg2 and Hep3B. Cancer Immunol.
Immunother. 53, 461-470
Se Jung Kim, Jee Young Sung, Ji Won Um, Nobutaka Hattori, Yoshikuni Mizuno, Keiji Tanaka, Seung R. Paik, Jongsun Kim,
Kwang Chul Chung (2003) Parkin cleaves intercellular a-synuclein inclusions via the activation of calpain. J. Biol. Chem. 278,
Eui-Nam Lee, Sun-Young Lee, Daekyun Lee, Jongsun Kim, Seung R. Paik (2003) Lipid interaction of a-synuclein during the
metal-catalyzed oxidation in the presence of Cu2+ and H2O2. J. Neurochem. 84, 1128-1142.
Sang Myun Park, Han Young Jung, Hyun Ok Kim, Hyangshuk Rhim, Seung R. Paik, Kwang Chul Chung, Jeon Han Park,
Jongsun Kim (2002) Evidence that -synuclein functions as a negative regulator of Ca2+-dependent -granule release from
human platelets. Blood 100, 2506-2514.
Yong-Joon Chwae, Mi Jung Chang, Sang Myun Park, Ho Yoon, Hyun-Joo Park, Se Jong Kim, Jongsun Kim (2002)
Molecular mechanism of the activation-induced cell death inhibition mediated by a p70 inhibitory killer cell Ig-like receptor
in Jurkat T cells. J. Immunol. 169, 3726-3735.
Sang Myun Park, Han Young Jung, Thomas D. Kim, Jeon Han Park, Chul-Hak Yang, Jongsun Kim (2002) Distinct roles of the
N-terminal-binding domain and the C-terminal-solubilizing domain of a-synuclein, a molecular chaperone. J. Biol. Chem. 277,
Sang Myun Park, Han Young Jung, Kwang Chul Chung, Hyangshuk Rhim, Jeon Han Park1, Jongsun Kim (2002)Stress-
Induced Aggregation Profiles of GST-a-synuclein Fusion Proteins: Role of the C-terminal Acidic Tail of a-synuclein in Protein
Thermosolubility and Stability. Biochemistry, 41, 4137-4146.
Yong-Seok H대, Jung Min Ryu, Sang Myun Park, Jeon Han Park, Hyun-Chul Lee, Kwang Yeon Hwang, Jongsun Kim (2002)
Sreuctural basis for inhibition of protein tyrosine phosphatases by Keggin compounds phosphomolybdate and
phosphotungstate. Exp. Mol. Med. 34, 211-223.
Thomas. D. Kim, Seong-Eun Cho, Chul Hak Yang, Jongsun Kim (2001) Analysis of FcgRIII and IgG Fc Polymorphism Reveals
Functional and Evolutionary Implications of Protein -Protein Interaction. J. Mol. Evol., 53, 1-91.
Sung, JY, Kim, J, Paik, SR, Park, JH, Ahn, YS, Chung, KC (2001) Induction of neuronal cell death by Rab5a-dependent
endocytosis of a-synuclein. J. Biol. Chem. 276, 27441-27448.
Kim, YS, Lee, D, Lee, EK, Sung, JY, Chung, KC, Kim, J, Paik, SR (2001) Multiple ligand interaction of a-synuclein aggregates
in the presence of Ab25-35, copper, and eosin. Brain Research 908, 93-98.
Thomas D. Kim, Hyun Jeong Ryu, Hyun Il Cho, Chul-Hak Yang, Jongsun Kim (2000) Thermal Behavior of Proteins: Heat-
Resistant Proteins and Their Heat-induced Secondary Structural Changes. Biochemistry 39, 14839-14846.
Thomas D. Kim, Seung R. Paik, Chul-Hak Yang, Jongsun Kim (2000) Structural Changes in alpha-synuclein affect its
chaperone-like activity in vitro. Protein Science 9(12) 2489-2496.
Daeho Kwon, Yong-Joon Chwae, In Hong Choi, Jeon Han Park, Se Jong Kim, Jongsun Kim (2000) Diversity of the p70 Killer
Cell Inhibitory Receptor (KIR3DL) Family Members in a Single Individual. Mo. Cells. 10, 54-60.
Eui Cheol Shin, Seong Eun Cho, Dong-Kee Lee, Man-Wook Hur, Seung R. Paik, Jeon Han Park and Jongsun Kim (2000)
Expression Patterns of a-Synuclein in Human Hematopoietic Cells and in Drosophila at Different Developmental Stages. Mol.
Cells. 10, 65-70.
Paik, S. R., Shin, H.-J., Lee, J.-H., Chang, C.-S., and Kim., J (1999) Copper(II)-induced self-oligomerization of -synuclein.
Biochemical Journal, 339: 821-828.
Yong-Joon Chwae, Seong Eun Cho, Se Jong Kim and Jongsun Kim (1999)Diversity of the Repertoire of p58 Killer Cell
Inhibitory Receptors in a Single Individual. Immunol. Lett. 68, 267-274.
Hyun Il Cho, Chae Gyu Park and Jongsun Kim (1999) The Cytoplasmic Tail of Killer Inhibitory Receptor (KIR) Associates
with TCR z in a phosphorylation dependent manner. Immunol. Lett. 68, 339-345.
Hyun Il Cho, Chae Gyu Park and Jongsun Kim (1999) Reconstitution of Killer Cell LInhibitory Receptor (KIR) mediated Signal
Transduction Machinery in a Cell-free Model System. Archives of Biochemistry and Biophysics 368, 221-231.
Jeon-Soo Shin, Eui-Cheol Choi, Jongsun Kim, In-Hong Choi, Jeon Han Park, Se-Jong Kim (1999) Monoclonal antibodies
with various reactivity to p58 killer inhibitory receptors. Hybridoma 18, 521-527.
Jongsun Kim, Yong Joon Chwae, Mi Yeon Kim, In Hong Choi, Jeon Han Park, Se Jong Kim (1997) Molecular basis of HLA-C
recognition by p58 natural killer cell inhibitory receptors. J. Immunology 159:3875-3882.
Seung R. Paik, Ju-Hyun Lee, Do-Hyung Kim, Chung-Soon Chang, Jongsun Kim (1997) Alminum-induced structural
alterationsof the precursor of the Non-Ab component of Alzheimer's disease amyloid. Archives of Biochemistry Biophysics
Zhe Piao, Jongsun Kim, Nam Kyu Kim, Sung Hoon Noh, Jae Y. Ro, Hoguen Kim (1997) Relationship between microsatellite
instability and histologic types of colorectal carcinoma. Oncology Reports 4:791-794.
Jongsun Kim (1997) Evidence that the NACP has an extended structure primarily composed of random-coil. Mol.
Cells 7:78-83.
Jongsun Kim, Mi-Yeon Kim, Yong Joon Chwae, Jeon Han Park (1997) Reconstitution of class I MHC molecules expressed
inE. coli and complexed with single antigenic peptides. J. Kor. Med. Sci. 12:280-285.
Mi-Yeon Kim, Jongsun Kim (1997) Reconstitution and binding analysis of a human ab TCR restricted to the HLA-A2/MAG
peptide complex. Kor. J. Immunol. 19:197-207.
David N. Garboczi, Ursula Utz, Partho Ghosh, Alpna Seth, Jongsun Kim, Esther A. E. VanTienhoven, William E. Biddison,
Don C. Wiley (1996) Assembly, specific binding, and crystallization of a human TCR and the class I MHC molecule HLA-A2.
J. Immunology 157:5403-5410.
Jongsun Kim, Esther van Tienhoven, David N. Garboczi, Ursule Utz, Mi-Yeon Kim, Don C. wiley. (1996) Specific binding of a
soluble recombinant b-chain T-cell antigen receptor to TSST-1, a superantigen. Mol. Cells 6:590-596.
Jongsun Kim (1995) Superantigen and class II MHC molecules. J. Kor. Med. Sci. 10, 393-398.
Jongsun Kim, R. G. Urban, J. L. Strominger, D. C. Wiley (1994) Toxic shock syndrome toxin-1 complexed with a human class
II major histocompatibility molecule HLA-DR1. Science 266, 1870-1875.
Jongsun Kim, D. C. Rees (1994) Nitrogenase and biological nitrogen fixation. Biochemistry 33, 387-397.
Jongsun Kim, D. Woo, D. C. Rees (1993) X-ray crystal structure of nitrogenase molybdenum-iron protein from Clostridium
pasteurianum at 3.0A resolution. Biochemistry 32, 7104-7115.
M. K. Chan, Jongsun Kim, D. C. Rees (1993) The nitrogenase FeMo-cofactor and P-cluster pair: 2.2 A resolution
structures. Science 260, 792-794.
D. C. Rees, Jongsun Kim, et al. (1993) Crystal structures of the iron-protein and molybdenum-iron protein of nitrogenase.
The ACS Symposium series. 535, 170-185.
D. C. Rees, M. K. Chan, Jongsun Kim (1993) Structure and Function of Nitrogenase. Adv. Inorg. Chem. 40, 89-119.
Jongsun Kim, D. C. Rees (1992) Crystallographic structure and functional implifications of the nitrogenase molybdenum-iron
protein from Azotobacter vinelandii. Nature 360, 553-560.
Jongsun Kim, D. C. Rees (1992) Structural models for the metal centers in the nitrogenase molybdenum-iron protein.
Science 257, 1677-1682.

[특허 및 기술 개발 경험]
국내특허등록 : HSP 90a를 포함하는 암 관 또는 반이러스 질환 지료용 조성물 (제 20-1594403 호)
국내특허출원: HSP 90a를 포함하는 암 또는 바이러스 질환 치료용 조성물 (제 10-1594403 호)
국내특허출원: NK 세포 활성화 물질, NK 세포 및 이들을 포함하는 약제학적 조성물, 07년 3월 28일 출원 (10-2007-0086643)
미국특허취득: Novel peptides conferring environmental stress resistance and fusion proteins including said peptides
국내특허취득: 안정화된 인간성장호르몬 융합단백질 (제2004-0033123호)
국내특허취득: 환경스트레스에 내성을 갖는 신규한 펩타이드 및 이를 포함하는 융합단백질(제2001-0072486호)

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